MENA CVD Orbuculum
An Orbuculum is a Crystal Ball, used for seeing things that would be otherwise invisible. In the context of MENA cerebrovascular Disorders (CVD) it’s a set of curating tools for Highliting and presenting the updated situation on cerebrovascular disorders and all related information from the trace pins of a MENA-SINO AI researcher and group of volunteered MENA experts.
Aim : is to moment by moment present the current situation , by numbers and statistics , for most of Cerebrovascular disorders in MENA region. where CVD facts and numbers in MENA region is under-represented either due to lack of data or difficulty of translating it to common language of the neuro-epidemiology.
1- Magnitude of the Problem (e.g. numbers , Incidence , Prevalence ..etc)
Developing new treatments for acute ischemic stroke that can quickly and safely intervene at the right place and time has been a particularly challenging endeavor characterized by a graveyard of clinical trial failures since the early 2000s. However, today the situation is changing due to technological developments related to stroke and recent advances in RNA-based medicines.
The Limitations Of Current Treatments For Acute Ischemic Stroke
Tissue plasminogen activator (tPA) is a clot-dissolving medicine approved in 1996 by the U.S. FDA to treat acute ischemic stroke. Unfortunately, tPA has several drawbacks that limit its clinical usage. These include its narrow therapeutic window of 3 to 4.5 hours, potential complications with IV administration, and a high risk of bleeding into the brain (hemorrhages), which due to a lack of reversibility is the most severe complication of treatment, limiting its usefulness for the majority of stroke patients.
A newer treatment option for patients with acute ischemic stroke is endovascular thrombectomy (EVT), a minimally invasive surgical procedure that use